Some quick notes about the group of diseases known as Polyglandular Autoimmune Syndrome (PGA).
- 2 types exist - PGA I and PGA II (PGA II is the MORE COMMON of the two)
- Each is a constellation of THREE diseases - but the diagnosis can be clinched by just having only 2 out of 3.
- The common link between the two is autoimmune Addison's disease
PGA I:
Parathyroid - autoimmune HYPOparathyroidism
Gandida (boo hoo....this represents a new low in mnemonic making) - chronic mucocutaneous candidiasis
Addison's disease
Chronologically, chronic mucocutaneous candidiasis appears first, followed by hypoparathyroidism, and lastly Addison's.
PGA II - also with Addison's and 1 of the 2:
1) Type 1 DM (contrast this with candidiasis, which is common in Diabetics)
2) autoimmune THYROID disease - more commonly Hashimoto's than Graves' (contrast this with Parathyroid involvement of PGA I)
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