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Just a few words to start off, I wouldnt' dare claim credit for ALL the mnemonics on this blog. In fact, a number of the cleverer mnemonics you see either are the good work of other doctors/students or have been shamelessly lifted out of medical books.

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Thursday, December 10, 2009

HUS/TTP - CRAFTY syndromes

Symptoms of HUS/TTP - CRAFTY (thank you ValueMD)

CNS symptoms -> visual symptoms, paresis, fits, changing conscious levels
Renal failure
Anemia -> Microangiopathic Haemolytic Anaemia (MAHA)
Fever
Thrombocytopenia
Y does it occur?
In HUS/TTP there are autoantibodies against the ADAM-TS13 metalloproteinase. ADAM-TS13 prevents the polymerisation of vWF -> hence when it is inhibited, vWF polymerises into larger, more active molecules - causing more platelets to clump to it and resulting in a fall in circulating platelet counts and intravascular microthrombi.

Causes include: E coli 0157, Shigella, Adenovirus, Pneumococcus, OCP, Pregnancy, SLE, HIV [haven't got a mnemonic for this list yet =( ]
at 2:45 AM

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