this mnemonic's pretty neat... got it from RxPG online and made some changes. enjoy!
Precipitants of Hepatic Encephalopathy - HEPATICS
Haemorrhage in the GI tract
Electrolyte disturbances (incl hypoNa+, hypoK+, hypovolaemia, acid/alkalosis, hypoxia)
Protein in the diet
Azotemia
TIPSS (transjugular intrahepatic porto-systemic shunt)
Infection (eg. spontaneous bacterial peritonitis)
Constipation
Sedatives (eg. opiates, benzos)
Monday, September 1, 2008
Inducers 'n' Inhibitors
Drug interactions are a bitch to study =(....
Hepatic enzyme INDUCERS - PC BRAS
Phenytoin
Carbamazepine
Barbiturates
Rifampicin
Alcohol (chronically)
Sulfapyrazine
so that's why they call them inducers......
Hepatic enzyme INHIBITORS - MAGIC VASES
Macrolides
Azoles (incl metronidazole)
Grapefruit
Isoniazid
C : cimetidine, chloramphenicol, ciprofloxacin
Valproate
Amiodarone
SSRIs
Esomeprazole
Sulphonamides
note that 'MAGIC VASES' isn't an exhaustive list; majority of drugs are enzyme inhibitors anyways, both pharmacokinetically and pharmacodynamically, rather than inducers
Hepatic enzyme INDUCERS - PC BRAS
Phenytoin
Carbamazepine
Barbiturates
Rifampicin
Alcohol (chronically)
Sulfapyrazine
so that's why they call them inducers......
Hepatic enzyme INHIBITORS - MAGIC VASES
Macrolides
Azoles (incl metronidazole)
Grapefruit
Isoniazid
C : cimetidine, chloramphenicol, ciprofloxacin
Valproate
Amiodarone
SSRIs
Esomeprazole
Sulphonamides
note that 'MAGIC VASES' isn't an exhaustive list; majority of drugs are enzyme inhibitors anyways, both pharmacokinetically and pharmacodynamically, rather than inducers
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