Erythema Nodosum VS Pyoderma Gangrenosum

Causes of Erythema Nodosum - DISSTend

Drugs (OCP, Penicillin, Sulfonamides)
IBD
Streptococcal infections
Sarcoid
TB
end - just a reminder that this the mnemonic for erythema nodosum


Causes of Pyoderma Gangrenosum - I Hate RPGs (I really do BTW...)
IBD
Hepatitis / Hematologic malignancies
RA
PG - reminder that it's Pyoderma Gangrenosum we're talking about here...

Jones' Criteria for Rheumatic Fever - Jones' Fear No-one

Jones' Criteria for Rheumatic Fever - JONES FEAR NO-1

In addition to evidence of recent Streptococcal infection (eg ASOT, positive throat swab c/s), we need either 2 major OR 1 major + 2 minor criteria

Major Criteria:

Joints - migratory, flitting polyarthritis

 - Carditis

Nodules (subcutaneous)

Erythema marginatum

Sydenham's chorea

Minor Criteria:

Fever

ESR raised

Arthralgia

Rheumatic fever previously

No-1 = First degree H/B on ECG

CHOLESTATIC drugs

Drugs causing cholestasis - CHOLESTATIC

CHlorpromazine

Ofloxacin

Largactil (ie chlorpromazine...cldn't think of any L-drugs)

Erythromycin

Sulfamethoxazole

+

Trimethoprim (Co-Trimox)

Augmentin (ie Co-Amoxiclav)

Tetracycline

Ibuprofen

Cimetidine

Mnemonics on poisoning

Indications for Hyperbaric O2 therapy in CO poisoning - NEPAL 40

Neurological toxicity (the most indicative being cerebellar symptoms)
ECG changes (the need for DCCV or Defib is a relative C/I to hyperbaric O2)
PregnAncy
Loss of consciousness
>40% CO-Hb


Symptoms of Lead Toxicity - LEAD (kudos to Esben Vogelius)

Lines across gums (Burton's Lines - poor dentition is usually a prerequisite for this sign, so rarer in children)
Erythrocyte stippling (also Sideroblastic anemia)
Abdominal pain
Drop, foot or wrist (Lead neuropathy is largely motor)
also, don't forget to look for neurodevelopmental symptoms

Graft versus Host Disease - Symptomology

acute GvHD occurs within 100 days of transplanting (immuno-competent) donor cells into an immuno-deficient host.

the classic triad of symptoms correspond to the abbreviation for this syndrome (ie. GvHD)

Gastroenteritis - diarrhoea
Hepatitis - biochemically evident, with or without jaundice
Dermatitis - ranges from mac-pap rash (that can be painful/pruritic) to exfoliative erythroderma

Bony Metastasis

Common Tumours Metastasising to bone - L.P. Thomas Kisses Best (or Breast)

Lung
Prostate
Thyroid
Kidney
Breast


Common sites of skeletal metastases - CASPERSKY (in order of frequency)

CA - reminder that bony malignancies are usually secondary
Spine
PElvis
Ribs
SKull
Y - looks a lil' like your femur 'eh? (ie Proximal Long Bones... ...rubbish I know =P)

HUS/TTP - CRAFTY syndromes

Symptoms of HUS/TTP - CRAFTY (thank you ValueMD)

CNS symptoms -> visual symptoms, paresis, fits, changing conscious levels
Renal failure
Anemia -> Microangiopathic Haemolytic Anaemia (MAHA)
Fever
Thrombocytopenia
Y does it occur?
In HUS/TTP there are autoantibodies against the ADAM-TS13 metalloproteinase. ADAM-TS13 prevents the polymerisation of vWF -> hence when it is inhibited, vWF polymerises into larger, more active molecules - causing more platelets to clump to it and resulting in a fall in circulating platelet counts and intravascular microthrombi.

Causes include: E coli 0157, Shigella, Adenovirus, Pneumococcus, OCP, Pregnancy, SLE, HIV [haven't got a mnemonic for this list yet =( ]